We design, deeply understand, and then scale up solutions to a wide range of delivery challenges.
CURRENT RESEARCH DIRECTIONS:
Combination therapies for personalized medicine
The most successful therapies involve delivery of multiple drugs. We aim to co-encapsulate therapeutics from multiple major categories (e.g. hydrophobic small molecules and hydrophilic biologics) into a single nanocarrier for simultaneous delivery to target sites in the body. Current applications of interest include vaccines, cancer therapies, and oral delivery.
Fundamental studies of drug liquid crystalline phase formation
Incorporating ionizable hydrophilic drugs into liquid crystalline phases offers a general approach for both nanoencapsulation and controlled release. We aim to formalize the relationship between liquid crystalline phase behavior and drug release in order to develop predictive models that will allow us to design stimulus-responsive and controlled-release nanoformulations for applications in humans and plants.
Nanoparticle delivery to plants
We aim to design low-cost nanocarriers that can be applied to plant leaves or roots and deliver critical agrochemicals to targets throughout the plant. We study how nanocarrier properties (e.g. size, surface chemistry) affect particle adhesion, internalization, and translocation across a variety of major crop species.
Nanoformulation process integration and scale-up
There is a strong translational element to our research, and we strive to develop processes that can be implemented at the industrial scale. To that end, we are interested in developing downstream unit operations to support the continuous nanoformulation platform Flash NanoPrecipitation, with the goal of improving product physical stability, reducing processing time, and promoting dosage form flexibility.